PUBLICATIONS

Vanden Heuvel, J.P., Kreder, D., Belda, B., Hannon, D.B., Nugent, C.A., Burns, K.A. and Taylor, M.J. Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferators WY14,643. Toxicol. Appl. Pharmacol. 188(3): 185 – 198, 2003

Sutter, T.R., He, X.R., Dimitrov, P., Xu, L., Narasimhan, G., George, E.O., Sutter, C.H., Grubbs, C., Savory, R., Stephan-Gueldner, M., Kreder, D., Taylor, M.J., Lubet, R., Patterson, T.A., and Kensler, T.W. Multiple comparisons model-based clustering and ternary pattern tree numerical display of gene response to treatment: procedure and application to the preclinical evaluation of chemopreventive agents. Mol. Cancer Ther. Dec 1(14): 1283-1292, 2002.

Cain, G.R., Tsai, K., Pulley, L.T., and Taylor, M. Detrusor Myopathy in Young Beagle Dogs. Toxicol. Path. 28(4): 565-567, 2000.

Bonhaus, D.W., Weinhardt, K.K., Taylor, M.J., DeSouza, A., McNeeley, P.M., Szczepanski, K.,
Fontana, D.J., Flippin, L.A., and Eglen, R.M. RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist. Neuropharmacology 36: 621-629, 1997.

Bonhaus, D.W., Weinhardt, K.K., Taylor, M.J., DeSouza, A., McNeeley, P.M., Szczepanski, K.,
Fontana, D.J., Trinh, J., Rocha, C.L., Dawson, M.W., Cao, Z., Wong, L. and Eglen, R.M. Biochemical and behavioral pharmacology of RS-102221, a subtype selective 5-HT2C receptor antagonist. CNS Drug Reviews 3: 278-293, 1997.

Day-Lollini, P.A., Stewart , G.R., Taylor, M. J., Johnson, R. M., and Chellman, G. J. Hyperplastic changes within the leptomeninges of the rat and monkey in response to chronic intracerebroventricular infusion of nerve growth factor. Exp. Neurol. 145, 24-37, 1997.

Clark, G.C. and Taylor, M.J. Tumor necrosis factor Involvement in the toxicity of TCDD: The role of endotoxin in the response. Exp. Clin. Immunogen., 11, 136-141, 1994.

Taylor, M.J., Lucier, G.W., Mahler, J.L., Thompson, M., Lockhart, A.C., and Clark, G.C. Inhibition of acute TCDD treatment with anti-tumor necrosis factor antibody or dexamethasone. Tox. Appl. Pharmacol., 117, 126-132, 1992.

Rosenthal, G.J., Craig, W.A. Corsini, E., Taylor, M. J., and Luster, M.I. Pentamidine blocks the pathophysiologic effects of endotoxemia through inhibition of cytokine release. Tox. Appl. Pharmacol., 112, 222-228, 1992.

Clark, G.C., Taylor, M.J., Lucier, G., and Luster, M.I. Tumor necrosis factor alpha involvement in 2,3,7,8 tetrachlorodibenzo p dioxin mediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus. Tox. Appl. Pharmacol., 111, 422-431, 1991.

Clark, G.C., Tritscher, A.M., Lucier, G.W., and Taylor, M.J. Dose-dependent increase in tumor necrosis factor alpha production in 2,3,7,8 tetrachlorodibenzo p dioxin exposed mice is Ah receptor dependent. Chemoshere, 23(11-12), 1817-1823, 1991.

Taylor, M.J., Lafarge Frayssinet, Luster, M.I., and Frayssinet, C. Increased Endotoxin sensitivity following T-2 toxin treatment is associated with increased absorption of endotoxin. Tox. Appl. Pharmacol., 109, 51-59, 1991.

Taylor, M.J., Smart, R.A., Sharma, R.P. Relationship of the hypothalamic pituitary-adrenal axis with chemically induced immunomodulation. I. Stress like response after exposure to T 2 toxin. Toxicology, 56, 179 195, 1989.

Hughes, B.J., Taylor, M.J., Sharma, R.P. Effects of verrucarin A and roridin A, macrocyclic trichothecene mycotoxins, on the murine immune system. Immunopharmacology 16, 79 87, 1988.

Reddy, R.V., Taylor, M.J., and Sharma, R.P. Evaluation of citrinin toxicity on the immune system in mice. J. Fd. Prot. 51 (1), 32 36, 1988.

Srisuchart, B., Taylor, M.J., and Sharma, R.P. Alternation of humoral and cellular immunity in manganese chloride treated mice. J. Toxicol. Environ. Hlth. 22, 91 99, 1988.

Reddy, R.V., Taylor, M.J., and Sharma, R.P. Studies of immune function of CD 1 mice exposed to Aflatoxin B1. Toxicology 43, 123 132, 1987.

Taylor, M.J., Hughes, B.J., and Sharma, R.P. Dose and time related effects of T 2 toxin on responses of murine splenic cell responses in vitro. Int. J. Immunopharmacol. 9, 107 113, 1987.

Kangsadalampi, K., Sharma, R.P., Taylor, M.J., and Salunkhe, D.K. Effect of protein deficiency and tween 60 on the pharmacokinetics of butylated hydroxyanisole and metabolites in male Sprague Dawley rats. Drug Nut. Inter. 4, 289 297, 1986.

Taylor, M.J., Reddy, R.V., Sharma, R.P. Immunotoxicity of repeated low level exposure to T 2 toxin, a trichothecene mycotoxin. Myco. Res. 1 (2), 57 64, 1985.

Willhite, C.C., Chow, F.I., Taylor, M.J., and Omay, S.T. Comparative pharmacokinetics of vitamin A (retinol) in rats and hamsters. Fd. Chem. Tox. 23 (1), 51 55, 1985.

Taylor, M.J., Bourcier, D.R., and Sharma, R.P. Distribution and pharmacokinetics of 3H butylated hydroxyanisole in female mice. Agents Action 15 (3 4), 454 458,1984.

Taylor, M. J., Frakes, R.A., Sharma, R.P., and Willhite, C.C. Pharmacokinetic differences of trypan blue in female Sprague Dawley and Long Evans rats. Fd. Chem. Tox. 22 (11), 875 878, 1984.

Bourcier, D.R., Sharma, R.P., Bracken, W.M., and Taylor, M.J. Cadmium copper interaction in intestinal mucosal cell cytosol of mice. Biol. Trace. Ele. Res. 5, 195 204, 1983.

Reddy, R.V., Sharma, R.P., and Taylor, M.J. Dose and time related responses of immunologic functions to aflatoxin B1 in mice. In: Developments in the Science and Practice of Toxicology, edited by A. W. Hayes, R. C. Schnell, and T. S. Miya, Elsevier Science Publishers B. V., pp 431 434, 1983.

Sharma, R.P., Taylor, M.J., and Bourcier, D.R. Subcellular distribution of alpha chaconine in mouse hepatocytes. Drug. Chem. Toxicol. 6 (2), 219 234, 1983.

Bourcier, D.R., Bracken, W.M., Taylor, M.J., and Sharma, R.P. Cadmium copper interaction: Effect of copper pretreatment and cadmium copper chronic exposure on the distribution and accumulation of cadmium, copper, zinc and iron in mice. Trace Sub. Env. Health, 1982, vol XVI, edited by D. D. Hemphil, Univ Missouri, Columbia, pp 273 279.

Book Chapters

Taylor, M.J., Sharma, R.P., and Luster, M.I. Selective Effects of T 2 Toxin and Ochratoxin A on Immune Functions. In: Microbial Toxins in Foods and Feeds, Cellular and Molecular Modes of Action, edited by A. E. Poland, V. R. Dowell, Jr., and J. L. Richard, Plenum Press, NY, pp. 489-495, 1990.

Taylor, M.J. Immunotoxicology of Trichothecene Mycotoxins. In: Biodeteriation Research vol. 3, edited by G.C. Llewellyn and C.E. O’Rear, Plenum Press, NY, pp. 85-101, 1990.

Taylor, M.J., Pang, V.F., and Beasley, V.R. Immunotoxicology of Trichothecene Mycotoxins. In: Trichothecene Mycotoxicosis: Pathophysiologic Effects, vol. II, edited by V.R. Beasley. CRC Press Inc., Boca Raton, FL, pp. 1 37, 1989.

Sharma, R.P. and Taylor, M.J. Animal Toxins. In: Handbook of Toxicology, edited by J.J. Haley and W.O. Berndt. Hemisphere, Washington, D. C., pp. 439 471, 1987.

Published Abstacts

Scicinski J, Oronsky B, Fitch WL, Taylor M, Gang L, Musick T, Marini J, Schicker M, Gohdes M, McKenzie D and Ridgewell R. Disposition of 14C-RRx-001 in rats after a singe intravenous administration and in blood from rats, dogs, monkeys and humans. Presented at the annual meeting of the International Society for the Study of Xenobiotics, Atlanta, GA, 2011.

Soloviev MV, Taylor MJ, Edwards TR, Culwell J, Rampersand CR, Filice JA, Argonza D, Calimlim M, Ordonio R, Afan R, Siacotos TJ, Schaefer GJ. Use of naltrexone to prevent adverse effects of sufentanil in beagle dogs. Toxicologist, 25, 473, 2005.

Soloviev MV, Taylor MJ, Mertens JJWM, Schaefer GJ, Wilkinson GT, Edwards TR, Chengelis CP. Continuous evaluation of subcutaneous temperature in rats. 10th International Congress of Toxicology, 2004.
Burns, K.A., Kreder, D., Belda, B., Nugent, C., Taylor, M. and Vanden Heuvel, J. Comprehensive analysis of gene expression in hepatoma cells exposed to the peroxisome proliferators WY-14,643: Evidence of an autoregulatory pathway. Toxicologist 22, 1251, 2002.

Stewart , G.R., Day-Lollini, P.A., Taylor, M.J., Johnson, R.M., and Chellman, G.J. Hyperplastic changes within the leptomeninges in response to chronic ICV infusion of nerve growth factor. Society for Neuroscience, 1995.
Stewart , G.R. and Taylor, M.J. Co-administration of recombinant human ciliary neurotrophic factor and vincristine sulfate to CD-1 mice. International Congress of Toxicology, 1995.

Walligora, D.T., Loomis, M.G., Murphy-Hackley, P., Day-Lollini, P.A., and Taylor, M.J.
A technical feasibility study for chronic intracerebroventricular (ICV) drug delivery in the cynomolgus monkey. 45th AALAS annual meeting, 1994.

Germolec, D.R., Rosenthal, G. J., Taylor, M.J., Corsini, E., Craig, W.A. , and Luster, M.I.
A comparative assessment of metabolic enzyme levels in immune tissues. Toxicologist 11, 52, 1991.

Clark, G.C., Lucier, G.W., Luster, M.I., Thompson, M., Mahler, J., and Taylor, M.J. Tumor necrosis factor (TNF) antibodies and dexamethasone treatment reverse the acute toxicity of 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD). Toxicologist 11, 53, 1991.

Taylor, M.J., Clark, G.C., Lucier, G., and Luster, M.I. 2,3,7,8 tetrachlorodibenzo p dioxin increases the release of tumor necrosis factor alpha (TNF a) and induces ethoxyresorufin o deethylase activity in rat kupffer's cells (KCs). Toxicologist 10, 1101, 1990.

Taylor, M.J., and Frayssinet, C. Alteration of endotoxin sensitivity by T 2 toxin. Toxicologist 9, 59, 1989.

Taylor, M.J., Jayasekara, S., and Sharma, R.P. T 2 toxin immunomodulation is mediated by a stress like response. Toxicologist 7, 34 1987.

Hughes, B.J., Taylor, M.J., and Sharma, R.P. Immunopotentiation by verrucarin A in CD 1 mice. Toxicologist 6, 259, 1986.

Taylor, M.J., Srisuchart, B., and Sharma, R.P. Immunological assessment of ethanol treated mice. Toxicologist 6, 271, 1986.

Srisuchart, B., Taylor, M.J., and Sharma, R.P Alteration of humoral and cellular immunity in manganese chloride treated mice. Toxicologist 6, 68, 1986.

Taylor M. J., Hughes, B.J., and Sharma, R.P. In vitro dose and time related effects of T 2 toxin, a trichothecene mycotoxin, on murine splenic and thymic cell responses. Toxicologist 5, 50, 1985.

Reddy, R. V., Taylor, M.J., and Sharma, R.P. Evaluation of citrinin toxicity on the immune system of mice. Toxicologist 3, 86, 1984.

Taylor, M.J., Sharma, R.P., and Reddy, R.V. Effect of repeated low level T 2 toxin exposure on the murine immune system. Toxicologist 4, 109, 1984.

Bourcier, D.R., Sharma, R.P., Bracken, W.M., and Taylor, M.J. Cadmium copper interaction in intestinal mucosal cell cytosol of mice. Toxicologist 3, 41, 1983.

Reddy, R.V., Sharma, R.P., and Taylor, M.J. Dose and time related response of immunologic functions to aflatoxin B1 in mice. Tox. Lett. 18, Suppl. 14, 1983.

Taylor, M.J., Reddy, R.V., and Sharma, R.P. Evaluation of repated low level T 2 toxin exposure on the murine immune system. NIH Immunotoxicology Workshop, Research Triangle Park, NC, 1983.

Taylor, M.J., Reddy, R.V., and Sharma, R.P. Immunotoxicologic evaluation of rubratoxin B in male CD 1 mice. Toxicologist 3, 86, 1983.

Taylor, M.J., Bourcier, D.R., and Sharma, R. P. Tissue distribution of butylated hydroxyanisole (BHA) in the mouse. Pharmacologist 24, 225, 1982.

Sharma, R.P., Taylor, M.J., and Bourcier, D.R. Binding of alpha chaconine with subcellular organelles. Pharmacologist 23, 115, 1981.

Invited Speaker

The Nonclinical Safety Assessment of Human Recombinant Ciliary Neurotrophic Factor. Presented at Biotechnology-Derived Therapeutics: Current Perspectives in Pharmacology and Toxicology. Hosted by Mason Laboratories. 1995. South San Francisco, CA.

Immunotoxicology of Trichothecene Mycotoxins. Presented at the Annual Meeting of the Foundation for Immunotoxicology. 1988. Williamsburg, VA.

Selective Effects of T 2 Toxin and Ochratoxin A on Immune System Functions. Presented at the Symposium on Microbial Toxins in Foods and Feeds, Cellular and Molecular Modes of Action. Hosted by the United States-Japan Cooperative Program on the Development and Utilization of Natural Resources, Joint Panels on Toxic Microorganisms. 1988. Chevy Chase, MD.

Immunotoxicology of Trichothecene Mycotoxins. Presented at the Third Meeting of the American Biodeterioration Society. 1989. Washington, D.C.

Symposia

The Discovery, Pharmacology, Toxicology, and Application of Neurotrophic Factors in the Treatment of Human Disease. Chairpersons: M. Taylor and W. Slikker, Jr. Meeting of the Society of Toxicology, 1997. Cincinnati, OH.

NonClinical Safety Assessment
Michael Taylor , Ph.D., DABT
650-796-2683
 micjtay@gmail.com

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